Often a report of high blood potassium isn't true hyperkalemia. Instead, it may be caused by the rupture of blood cells in the blood sample during or shortly after the blood draw. Several things can cause hyperkalemia, including health problems and use of certain medications. Kidney failure. Kidney failure is the most common cause of high potassium. Summary. Hyperkalemia is found among people who take Nexium, especially for people who are female, 60+ old , have been taking the drug for 1 month, also take medication Lasix, and have High blood pressure. The FDA has warned that orally-administered Kayexalate, a treatment for hyperkalemia (high potassium levels) can reduce the effectiveness of other oral medications if taken at the same time. YOUR KIDNEYS AND HIGH POTASSIUM (HYPERKALEMIA) Are You At Risk? kidney.org Esomeprazole is a proton pump inhibitor (brand name Nexium, Essocam) which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells. By inhibiting the functioning of this transporter, the drug prevents formation of gastric acid. Hyperkalemia is found among people who take Esomeprazole sodium, especially for people who are female, 60+ old , have been taking the drug for 1 month, also take medication Lasix, and have High blood pressure. Learn More About Heartburn Medications Linked to Kidney Disease. The use of heartburn drugs Prilosec and Nexium has been linked to a number of serious potential side effects such as bone fractures, kidney disease and kidney failure.These complications can result in serious health consequences that can alter your life. Here you can read posts from all over the web from people who wrote about GERD and Hyperkalemia, and check the relations between GERD and Hyperkalemia Hyperkalemia is an excessive level of potassium in the bloodstream. Potassium has several important functions in the body. It is essential for the normal functioning of the muscles, heart, and nerves.